Four highlights of the hottest drug packaging

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Four highlights of drug packaging

first, flexible packaging

according to the report of the American flexible packaging Association, drug packaging will become the second largest economic growth point of the flexible packaging industry in the next five years

in the plastic composite film bag packaging of granules, powders, powders and capsules of traditional Chinese medicine, which are mainly popularized and applied in China, the following varieties are mainly developed

(1) biaxially oriented polypropylene (BOPP) film, which has good transparency, heat resistance and barrier properties, is used for the outer layer of composite packaging bags. Combining BOPP film with ld-peeva, EEA, EAA or aluminum foil with good heat sealing performance can greatly improve the stiffness and physical and mechanical properties of the composite film. If the BOPP film is coated with PVDC with excellent moisture-proof and barrier properties, its barrier performance can be greatly improved

(2) cast polypropylene film (CPP). It has good heat sealing property and is mostly used for the inner layer of composite packaging bags. After vacuum aluminizing, it can also be compounded with BOPP, pet, OPA and Pt

(3) polyester film (PET). It has excellent mechanical strength and rigidity, low heat resistance, drug resistance, transparency, gloss, water and oxygen transmittance, and has particularly good taste retention, which is unparalleled by other films

(4) polyvinylidene chloride film (PVDC). It is one of the best barrier films. In addition to pharmaceutical packaging, it is also widely used in the packaging of other products, such as meat products, cakes, tea, etc

II. Aluminum plastic blister packaging

aluminum plastic blister packaging of drugs is also called blister eye packaging. This packaging form has many advantages: first, it provides patients with a single dose of drug packaging, which is convenient and economical. Secondly, blister packaging has the advantages of fast production speed, low cost, small storage area and convenient transportation. Thirdly, it has good safety. Because the aluminum foil surface is printed with text instructions, it can avoid dispensing wrong drugs in the distribution process of a variety of tablets. Therefore, in the coming period, China will greatly increase high-quality blister packaging to meet the needs of the drug market. It is expected that blister packaging materials will account for 60%-70% of the tablet and capsule packaging of drugs in the future, and it is one of the drug packaging forms with the best development prospects at present

the aluminum foil used for blister packaging is the sealing material sealed on the hard piece of medical plastic polyvinyl chloride (PVC), so it is called the capping material. It is made of electrolytic aluminum with purity of 99% by calendering. It has the advantages of tasteless, electrical conductivity, shading, moisture resistance, gas resistance and good taste retention. Because the aluminum foil has a highly dense metal crystal structure, it can completely block any gas, water vapor and light that makes the longitudinal axis of the sample coincide with the center line of the upper and lower clamps, so it can most effectively protect the packaged object. In modern packaging, almost all products requiring opaque and high barrier composite materials use aluminum foil as barrier layer. Therefore, it is widely used. However, the quality of domestic medicinal aluminum foil is far from that of imported products

according to the actual situation reflected by several pharmaceutical blister packaging manufacturers, the blister packaging currently has the following problems:

(1) the number of pinholes in pharmaceutical aluminum foil is far from the requirements. Aluminum foil pinholes affect the barrier performance of aluminum foil. Especially for drug packaging, it is easy to make oxygen, water vapor and light penetrate and reduce the efficacy of drugs. Therefore, for medicinal aluminum foil, the national standard requires that there should be no pinhole with a diameter greater than 0.3 mm and a diameter of 0.5 mm The number of 3mm pinholes shall not be more than 1/m2. At present, few domestic products can meet this standard

(2) the thickness of medicinal aluminum foil is uneven and the tensile strength is low. The thickness of aluminum foil is uneven, which is easy to cause that the coating amount of adhesive in the coating process is difficult to reach the standard coating amount, thus affecting the heat sealing strength of aluminum foil and PVC hard sheet. The low tensile strength leads to the foil breaking after the unwinding tension is applied in the actual processing, which is not conducive to the normal production. These problems should be paid attention to by the raw material manufacturers

the largest amount of blister packaging materials is medicinal PVC hard sheet. As drugs are sensitive to moisture and light transmission, PVC hard sheets are required to have good barrier properties against moisture, light and odor. However, the PVC currently used is just not ideal in terms of moisture resistance. Therefore, the use of polyvinylidene chloride (PVDC) or its composite materials should be advocated in the future. The characteristics of PVDC are: high molecular weight, high density, regular structure, excellent moisture resistance, good oil resistance Drug resistance and solvent resistance, especially for oxygen, water vapor and dioxygen in air a) volume of tested product (W × D × H) It shall not exceed (20 ~ 35)% of the effective working space of the test chamber (20% is recommended). The carburized gas has excellent barrier performance. With the same thickness, PVDC has 1500 times as much oxygen barrier performance as PE, 100 times as much as PP and 100 times as much as pet. PVDC has better water vapor and oxygen barrier performance than PVC. In addition, the sealing performance, impact strength, tensile strength and other indicators of PVDC material can meet the special requirements of product packaging when the drug is formed by male mold, which is the development focus of drug packaging materials in the future. In addition, other composite materials, such as pvc/pvdc/pe, pvdc/opp/pe, pvc/pe and other dark brown composite plastic hard sheets, will also be widely used in blister packaging of drugs

III. single dose subcontracting

for a long time, most Chinese medicinal materials and their decoction pieces have been packed with sacks, Trichosanthes, cattail and other inferior materials. In recent years, although cartons and plastic bags have appeared, each package is hundreds of kilograms in size and tens of kilograms in size, which brings great inconvenience to consumers. After entering the 21st century, new concepts, new technologies and new materials are emerging, which has made great changes in the packaging of traditional Chinese medicine

in recent years, the packaging of Chinese herbal medicine and its pieces has been improved. Individual places have started to subcontract the single dose of Chinese herbal medicine and its pieces. However, on the whole, the packaging of Chinese herbal medicine and its pieces is still relatively primitive, which has affected the quality and safety of Chinese herbal medicine, and restricted the process of modernization and internationalization of Chinese pharmaceutical products

after single dose subcontracting, except for a few special drugs, weighing, dose dividing, bandaging and other links can be omitted in the operation, which greatly improves the production efficiency, shortens the waiting time for patients, reduces or avoids mistakes and omissions, and greatly improves the cleanliness and busy situation of the workshop

after a single dose of sealed packaging, traditional Chinese medicine and its decoction pieces can also be added with medium packaging and outer packaging according to the number of doses, so as to reduce the influence of natural factors such as air and sunlight on the decoction pieces and reduce the changes during storage and storage. At the same time, due to the standardization of packaging, it is also conducive to transportation and quality supervision and management. Under normal circumstances, driven by interests, some businesses intentionally adulterate and fabricate drugs, making it difficult to find them after mixing them into large packages. However, after single dose subcontracting, the pharmacists and patients are easy to identify, which makes it more difficult to fabricate and ensures that patients can take "reassuring drugs"

single dose subcontracting is only a change in the way of packaging and dispensing, and does not affect the special medication requirements of some clinicians. The author believes that the single dose subcontracting can refer to the code. The identification of the prescribed words in the textbook is the key to the 10 points in the search engine. As well as the general law of clinical drug dosage, the subcontracting shall be carried out according to 3G, 5g, 6G, 10g, 15g and other specifications. Toxic traditional Chinese medicines and precious drugs with a single dose of less than 3G, and grasses or leaves with a single dose of more than 30g, can still be prepared by using the previous balance and other tools, which will not restrict and affect the clinical use of traditional Chinese medicine

IV. capsule packaging

the relevant departments of neon estimated that in recent years, the global consumption of various capsules has reached billions of capsules every year, and its total sales account for about 1/4 of the total amount of pharmaceutical preparations

traditional capsules are usually divided into two categories, namely hard capsules (applicable to filling powder drugs) and soft capsules (applicable to vitamin E, vitamin A and other liquid drugs). In recent years, with the rise of global health food fever, a large number of liquid natural health food (such as pumpkin kernel oil, deep-sea fish oil, garlic oil, ginger oil and other natural plant extracts) are very popular in the market. The soft capsule processed with traditional gelatin as raw material is difficult to reflect the above characteristics of "green" health food due to its low transparency. In view of this, in recent years, foreign preparation manufacturers have launched an innovative "fully transparent liquid capsule" (the trade name is licaps). The capsule is made of non gelatin materials (such as "polypropylene polyacrylic acid core copolymer" and other high molecular polymers). It is highly transparent. Consumers can see the amount and color of the contents at a glance, thus creating a sense of trust and enhancing their desire to buy. It is reported that the fully transparent liquid capsule licaps has good drug resistance, humidity resistance and toughness, and its quality indicators fully meet the standards of the 24th edition of the "United States Pharmacopoeia". It is expected that the fully transparent liquid capsule will have a broad market prospect, and its appearance is a challenge to the traditional gelatin capsule. Baimuziyin)

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